To inspect the cancer immunotheraphy, tumor microenvironemt gain maximum attention where cancer cells and non-cancerous cell interact with each other equally. Tumor microenvironment is a complex ecology of cells that promote the cancer cell survival and enhance the tumor growth. Tumor associate macrophage is one of the key immune cells abundantly present in tumor microenvironment which accelerate many important features of tumor progression, including angiogenesis, tumour cell invasion, motility, and intravasation as well as metastasis. In few cases, 50% of tumor associate macrophage has been reported in the tumor mass which involves in a poor clinical response in the majority of cancers (Ashleigh R. Poh and Matthias Ernst et al.2018). There are two distict process by which macrophahges arise: Yolk sac derived macrophages and Bone marrow-derived macrophages. Yolk sac – derived macrophages originate from developmental hematopoiesis and Bone marrow macropahes originate from monocyte precursors. TAMs are mainly originate from circulating monocytes.