J O B syndrome HYPERIMMUNOGLOBULIN E PATHOPHYSIOLOGICAL BASIS REFERENCESSUBMITTED BY

J O B
syndrome
HYPERIMMUNOGLOBULIN E
PATHOPHYSIOLOGICAL
BASIS
REFERENCESSUBMITTED BY:SyndromeNorayda P. Garcia
3 NUR 4
De, A ., B ra hm ach ari, A ., B andyo padhya y, S .,&
M andal, T . ( J u ly , 2 012). J o b s yn dro m e a nd it s
m anagem ent. In te rn atio nal J o urn al o f A dva nce s in
P harm acy, B io lo gy a nd C hem is tr y ,1 ( 3 ). R etr ie ve d
fr o m h ttp ://w ww.ija pbc.c o m /file s/2 4-1 329.p df
H yp erim munoglo bulin e s yn dro m e.( n .d .) . R etr ie ve d
fr o m h ttp s://m edlin eplu s.g ov/e ncy/a rtic le /0 01311.h tm
J o b s yn dro m e. ( n .d .) . R etr ie ve d fr o m
http s://w ww.x p ertd ox.c o m /d is e ase –
descrip tio n/J o b% 20S yn dro m ehttp s://w ww.x p ertd ox.c
o m /d is e ase -d escrip tio n/J o b% 20S yn dro m e
Jyo nouch i, H . ( 2 015). H yp erim munoglo bulin em ia E
( J o b) s yn dro m e. R etr ie ve d fr o m
http s://e m edic in e.m edsca pe.c o m /a rtic le /8 86988-
ove rv ie w #a4
H yp erim munoglo bulin E s yn dro m e. ( n .d .) . R etr ie ve d
fr o m
http ://w ww.n atu ra lliv in gce nte r.n et/n s/D is p la yM onogr
aph.a sp ?
S to re ID =b571dew xvcs9 2jj2 00akh m ccq a7w 8v7 5& D o
cID =alle rg y-h ie s
Immunologic
Disorders

WHAT IS JOB SYNDROME?          I t i s a c o n d it io n t h at a ffe cts s e ve ra l b od y
sy ste m s, p art ic u la rly t h e i m mun e s y ste m .
Recu rre n t i n fe ctio n s a re c o m mon i n p eo p le
w it h t h is c o n d it io n . A ffe cte d i n d iv id uals t e n d
to h ave f r e q uen t b ou ts o f p neu m on ia , w hic h
a re c a u se d b y c e rt a in k in d s o f b acte ria t h at
in fe ct t h e l u n gs a n d c a u se i n fla m matio n .

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        H IE S i s a r a re p rim ary i m mun od efic ie n cy
c h ara cte riz e d b y r e cu rre n t e cze m a, s k in
a b sc e sse s, l u n g i n fe ctio n s, e o sin op hil ia a n d
h ig h s e ru m l e ve ls o f I g E . 
PREVENTION
T h ere i s n o p ro ve n w ay
to p re ve n t H yp er I g E
sy n d ro m e. G ood g en era l
h yg ie n e i s h elp fu l i n
p re ve n tin g s k in
in fe ctio n s.
S o m e p ro vid ers m ay
re co m men d p re ve n tiv e
a n tib io tic s f o r p eo p le
w ho d eve lo p m an y
in fe ctio n s, e sp ecia lly
w it h S ta p hylo co ccu s
au re u s. T h is t re atm en t
d oes n ot c h an ge t h e
co n d it io n , b ut i t c a n
le sse n i t s c o m plic a tio n s
What are the causes?
• B on e a n d t o oth d efe cts , i n clu d in g
fr a ctu re s a n d l o sin g t h e b ab y t e eth l a te
• E cze m a
• S kin a b sc e sse s a n d i n fe ctio n
• R ep eate d s in us i n fe ctio n s
• R ep eate d l u n g i n fe ctio n s
• l o n g-t e rm , s e ve re s k in i n fe ctio n s.
•g en etic c h an ge ( m uta tio n )
• H ig h l e ve l o f a n a n tib od y ” I g E “.
• U nkn ow n
SIGNS & SYMPTOMS
Possible complications
• R ep eate d i n fe ctio n s
• S ep sis
Treatment for Job syndrome
T h ere i s n o k n ow n c u re f o r t h is c o n d it io n .
T h e g oal o f t re atm en t i s t o c o n tro l t h e i n fe ctio n s.
M ed ic a l m an ag em en t i n clu d e:
• A ntib io tic s
• A ntif u n gal a n d a n tiv ir a l m ed ic in es 
• C ell t h era p y
• G en e t h era p y
So m etim es, s u rg ery i s n eed ed t o d ra in a b sc e ss.
NURSING MANAGEMENT
A sse ss th e c lie nt fo r a ny s ig ns a nd s ym pto m s o f in fe ctio n
A sse ss h is to ry o f p ast in fe ctio ns ( ty p e & fr e quency); s ig ns
and s ym pto m s o f a ny c u rre nt s kin , r e sp ir a to ry ,o ra l,
g astr o in te stin al o r g enit o urin ary in fe ctio n
M onit o r v it a l s ig ns a nd d eve lo pm ent o f p ain .
M onit o r la bora to ry v a lu es
R eport fo r a ny s kin a nd o ra l le sio ns
A usu clt a te b re ath s o unds
P ro m ote g ood d enta l h yg ie ne
M ain ta in r e sp ir a to ry a nd b ow el fu nctio n
E nco ura ge c lie nt to c o ugh a nd p erfo rm d eep b re ath in g
exe rc is e s a t r e gula r in te rv a ls .
E duca te th e c lie nt a bout g ood d enta l h yg ie ne
A ssis t th e c lie nt in m anagin g s tr e ss.